Selected publications

Tumor endothelial cell autophagy is a key vascular-immune checkpoint in melanoma - Verhoeven J., Jacobs K., Rizzollo F., Lodi F., Hua Y., Pozniak J., Srinivasan A.N., Houbaert D., Shankar G., More S., Schaaf M.,  Lakic N.D., Ganne M., Lamote J., Van Weyenbergh J., Boon L., Bechter O., Bosisio F., Uchiyama Y., Bertrand J.M., Marine J.C., Lambrechts D., Bergers G., Agrawal M., Agostinis P. - 2023 - EMBO Mol Med - PubMed

PERK recruits E-Syt1 at ER-mitochondria contacts for mitochondrial lipid transport and respiration - Sassano ML, van Vliet AR, Vervoort E, Van Eygen S, Van den Haute C, Pavie B, Roels J, Swinnen JV, Spinazzi M, Moens L, Casteels K, Meyts I, Pinton P, Marchi S, Rochin L, Giordano F, Felipe-Abrio B, Agostinis P. - 2023 - J Cell Biol - Pubmed

The “Yin and Yang” of unfolded protein response in cancer and immunogenic cell death - Rufo, N., Yang, N., De Vleeschouwer, S., Agostinis, P. - 2022 - Cells - PubMed

ER-mitochondria contact sites; a multifaceted factory for Ca2+ signaling and lipid transport - Sassano M.L., Felipe Abrio, B., Agostinis, P. - 2022 - Front Cell Dev Biol - PubMed

Eating your own fat to stay fit: Lipophagy sustains lymphangiogenesis - Mece, O., Houbaert, D., Agostinis, P. - 2022 - Autophagy - PubMed

Lipid droplet degradation by autophagy connects mitochondria metabolism to Prox1-driven expression of lymphatic genes and lymphangiogenesis - Meçe, O., Houbaert, D., Sassano, M-L., Durré, T., Maes, H., Schaaf, M., More, S., Ganne, M., Garcia-Caballero, M., Borri, M., Verhoeven, J., Agrawal, M., Jacobs, K., Bergers, G., Blacher, S., Ghesquière, B., Dewerchin, M., Swinnen, J.V., Vinckier, S., Soengas, M.S., Carmeliet, P., Noël, A., Agostinis, P. - 2022 - Nature Communications - PubMed

Stress-induced inflammation evoked by immunogenic cell death is blunted by the IRE1α kinase inhibitor KIRA6 through HSP60 targeting - Rufo N, Korovesis D, Van Eygen S, Derua R, Garg AD, Finotello F, Vara-Perez M, Rožanc J, Dewaele M, de Witte PA, Alexopoulos LG, Janssens S, Sinkkonen L, Sauter T, Verhelst SHL, Agostinis P. - 2021 - Cell Death Differ. - PubMed

The lysosome as a master regulator of iron metabolism - Rizzollo F, More S, Vangheluwe P, Agostinis P.-2021 - Trends Biochem Sci.- PubMed

BNIP3 promotes HIF-1α-driven melanoma growth by regulating NCOA4-mediated intracellular iron homeostasis - Vara-Pérez, M., Rossi, M., Van den Haute, C., Maes, H., Sassano, M.L., Venkataramani, V., Michalke, B., Romano, E., Rillaerts, K., Garg, A., Schepkens, C., Bosisio, F., Wouters, J., Oliveira, A.I., Vangheluwe, P., Annaert, W., Swinnen, J., Colet, J.M., van den Oord, J.J., Fendt, S., Mazzone, M., Agostinis, P. - 2021 - EMBO Journal - PubMed

Endothelial cell autophagy in homeostasis and cancer - Verhoeven, J., Baelen, J., Agrawal, M., Agostinis, P. - 2021 - FEBS Letters - PubMed

ATP13A2 deficiency disrupts lysosomal polyamine export - van Veen S, Martin S, Van den Haute C, Benoy V, Lyons J, Vanhoutte R, Kahler JP, Decuypere JP, Gelders G, Lambie E, Zielich J, Swinnen JV, Annaert W, Agostinis P, Ghesquière B, Verhelst S, Baekelandt V, Eggermont J, Vangheluwe P. - 2020 - Nature -  PubMed

Kinase Photoaffinity Labeling Reveals Low Selectivity Profile of the IRE1 Targeting Imidazopyrazine-Based KIRA6 Inhibitor - Korovesis D, Rufo N, Derua R, Agostinis P, Verhelst SHL. - 2020 - ACS Chem Biol. - PubMed

Trial watch: dendritic cell vaccination for cancer immunotherapy - Sprooten, J., Ceusters, J., Coosemans, A., Agostinis, P., De Vlesschouwer, S., Zitvogel, L., Kroemer, G., Galluzzi L., Garg, A.D. - 2019 - Oncoimmunology - Pubmed

Type I interferons and dendritic celles in cancer immunotherapy - Sprooten, J., Agostinis P., Garg, A.D - 2019 - Inr Rev Cell Molec Biology - Pubmed

Mitophagy in Cancer: A Tale of Adaptation - Vara-Perez, M., Felipe-Abrio, B., Agostinis, P. - 2019 - Cells - Pubmed

Autophagy in endothelial cells and tumor angiogenesis - Schaaf, M.B., Houbaert, D., Mece, O., Agostinis, P. - 2019 - Cell death and differentiation - Pubmed

Lysosomal Pathways and Autophagy Distinctively Control Endothelial Cell Behavior to Affect Tumor Vasculature - Schaaf, M.B., Houbaert, D., Mece, O., To, S.K., Ganne, M., Maes, H., Agostinis, P - 2019 - Frontiers in Oncology - Pubmed

BNIP3 contributes to the glutamine-driven aggressive behavior of melanoma cells - Vara-Perez, M., Maes, H., Van Dingenen, S., Agostinis, P - 2019 - Biological Chemistry - Pubmed

Sustained SREBP-1-dependent lipogenesis as a key mediator of resistance to BRAF-targeted therapy - Talebi A, Dehairs J, Rambow F, Rogiers A, Nittner D, Derua R, Vanderhoydonc F, Duarte JAG, Bosisio F, Van den Eynde K, Nys K, Pérez MV, Agostinis P, Waelkens E, Van den Oord J, Fendt SM, Marine JC, Swinnen JV. - 2018 - Nat Commun. - PubMed

BNIP3 modulates the interface between B16-F10 melanoma cells and immune cells - Romano, E., Rufo, N., Korf, H., Mathieu, C., Garg, A.D., Agostinis, P - 2018 - Oncotarget - Pubmed

Defining the role of the tumor vasculature in antitumor immunity and immunotherapy - Schaaf, M., Garg, A., Agostinis, P - 2018 - Cell death & disease - Pubmed

PERK mediates ER-PM contact site formation by interacting with Filamin A and regulating F-actin dynamics - Van Vliet A, Giordano F, Gerlo S, Segura I, Van Eygen S, Molenberghs G, Rocha S, Houcine A, Derua R, Verfaillie T, Vangindertael J, De Keersmacher, Waelkens E, Tavernier J, Hofkens J, Annaert W, Carmeliet P, Samali A, Mizuno H, Agostinis P - 2017 - Molecular Cell - Pubmed

An autophagy-driven pathway of ATP secretion supports the aggressive phenotype of BRAFV600E inhibitor-resistant metastatic melanoma cells - Martin S, Dudek-Peric AM, Garg AD, Roose H, Demirsoy S, Van Eygen S, Mertens F, Vangheluwe P, Vankelecom H, Agostinis P. - 2017 - Autophagy - PubMed

Pathogen response-like recruitment and activation of neutrophils by sterile immunogenic dying cells drives neutrophil-mediated residual cell killing - Garg AD, Vandenberk L, Fang S, Fasche T, Van Eygen S, Maes J, Van Woensel M, Koks C, Vanthillo N, Graf N, de Witte P, Van Gool S, Salven P, Agostinis P.- 2017 - Cell Death Differ. - PubMed

Dendritic cell vaccines based on immunogenic cell death elicit danger signals and T cell-driven rejection of high-grade glioma - Garg AD, Vandenberk L, Koks C, Verschuere T, Boon L, Van Gool SW, Agostinis P - 2016 - Science Translational Medicine - Pubmed

Tumor vessel normalization by chloroquine independent of autophagy - Maes H, Kuchnio A, Peric A, Moens S, Nys K, De Bock K, Quaegebeur A, Schoors S, Georgiadou M, Wouters J, Vinckier S, Vankelecom H, Garmyn M, Vion AC, Radtke F, Boulanger C, Gerhardt H, Dejana E, Dewerchin M, Ghesquière B, Annaert W, Agostinis P, Carmeliet P. - 2014 - Cancer Cell. - PubMed

Immunogenic cell death and DAMPs in cancer therapy - Krysko DV, Garg AD, Kaczmarek A, Krysko O, Agostinis P*, Vandenabeele P*.- 2012 - Nat Rev Cancer. - PubMed

PERK is required at the ER-mitochondrial contact sites to convey apoptosis after ROS-based ER stress - Verfaillie T, Rubio N, Garg AD, Bultynck G, Rizzuto R, Decuypere JP, Piette J, Linehan C, Gupta S, Samali A, Agostinis P. - 2012 - Cell Death Differ. - PubMed

A novel pathway combining calreticulin exposure and ATP secretion in immunogenic cancer cell death - Garg AD, Krysko DV, Verfaillie T, Kaczmarek A, Ferreira GB, Marysael T, Rubio N, Firczuk M, Mathieu C, Roebroek AJ, Annaert W, Golab J, de Witte P, Vandenabeele P, Agostinis P. - 2012 - EMBO J. - PubMed